Yan Zhao1,
Jie Chen1,
Yi Xu1,
Geling Liu1,
Jia Cui1,
Liping Liu1,
Jie Gao2 
For correspondence:- Jie Gao Email: gtcp6j@163.com
Accepted: 29 July 2022 Published: 28 August 2022
Citation: Zhao Y, Chen J, Xu Y, Liu G, Cui J, Liu L, et al. Combined administration of Gegen Yinlian decoction and metformin ameliorates liver metabolic disorder in rats by regulating miR-195-5p/IRS1/PI3K/AKT axis. Trop J Pharm Res 2022; 21(8):1647-1653 doi: 10.4314/tjpr.v21i8.10
© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the effect of Gegen Yinlian decoction (GYD), made from lobed kudzuvine root, baicalensis, huanglian and liquorice, and metformin on liver metabolism dysfunction in type 2 diabetes mellitus (T2DM) rats.
Methods: Wistar rats were treated with high-fat diet and a single intraperitoneal streptozotocin (STZ) injection to establish T2DM model. Thereafter, the T2DM-rats were treated with GYD and metformin (GYD/metformin). Serum triglyceride (TG), TC, LDL, and HDL levels, as well as glucose and insulin tolerance of the rats were evaluated. Furthermore, the effects of GYD/metformin treatment on the ex
Results: After GYD-metformin treatment, the metabolic indicators in T2DM rats significantly improved (p < 0.05). However, there was decrease in t liver miR-1955p ex
Conclusion: Combination of GYD with metformin ameliorated dysfunctional liver metabolism via control of miR-195-5p/IRS1/PI3K/AKT axis.
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